COMPATIBILITY STUDIES

Show if you are also molecularly compatible

PRECON STUDIES

GUARANTEE THEIR FUTURE HEALTH TODAY

PRECON-BLUE
logo precon en azul

For any COUPLE

Analysis of >540 genes (>770 conditions):

  • All Newborn Screening Test diseases
  • Most severe diseases
  • Most common diseases
  • Paediatric diseases
  • Diseases included in any other commercial test

Results in 6 - 7 weeks

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PRECON-GOLD
logo precon en oro

For curious COUPLES

Analysis of >2.700 genes (>3.180 conditions):

  • All diseases in the PRECON-BLUE
  • Severe and less severe conditions
  • Less frequent but severe diseases
  • Paediatric and later-onset conditions
  • The most comprehensive carrier test on the market

Results in 6 - 8 weeks

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PRECON-SINGLE
logo precon single

For SINGLE PARENTS

Analysis of >540 genes (>770 conditions):

  • All Newborn Screening Test diseases
  • Most severe diseases
  • Most common diseases
  • Paediatric diseases
  • Diseases included in any other commercial test

Results in 6 - 7 weeks

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After ordering a PRECON study you will get a 5% off discount in any PRENAT study.

WHY DOING A PRECON STUDY?

icon: statistics

Today, there are about 8,000 known rare diseases, and over 5,500 of these have a genetic origin; that is, they can be transmitted to our children. It is estimated that there are close to 30 million people in the European Union and about 300 million people globally with one of these conditions.

icon: DNA loop

More than half of these genetic conditions (~ 3,200) are recessive, that is, they can be passed on to our offspring without us suffering or manifesting them. Diseases such as cystic fibrosis, sickle cell anemia, fragile X syndrome, phenylketonuria, or spinal muscular atrophy.

icon: affected people

About 1 in 300 babies -born to healthy parents- suffer from a genetic recessive disease. Most of these diseases are collectively more common and more - or equally - severe than better known diseases like Down syndrome (1 in 700 babies), and do not depend on the parents' age.

WHAT ARE THE BENEFITS OF A PRECON study?

1. Knowing your risk of having a baby with an inherited condition and thus taking informed decisions.

2. Carrying out a more exhaustive and targeted monitoring during pregnancy and after birth:

  • ⇩  Thus decreasing mortality in certain diseases
  • ⇨  Allowing the use of more effective personalized treatments
  • ⇩  Reducing complications and sequelae of the disease
  • ⇧  Considerably improving the quality of life of the family

3. Completely avoid transmitting the disease using alternative fecundation methods (e.g. in vitro fertilization)

photo: happy kid

HOW DOES THE STUDY WORK?

The aim of our Genetic Compatibility Study (GCS) [PRECON] is to detect if you are carriers of a rare recessive genetic disease, which you are not aware of.

The study is done with the DNA extracted from your saliva. All the coding regions (exons) of your DNA, which represent ~1% of the genome, are simultaneoulsy captured and read (sequenced) in an procedure known as Whole Exome Sequencing (WES). Exons are the regions of the gene that get translated into the different parts of the protein.

The information obtained from your exome will be decoded so that we can detect if you carry mutations in genes known to cause autosomal recessive disorders. These mutations result in reduced protein function or no protein function and consequent development of disease.

cromosomas, genes, proteinas

HOW ARE RECESSIVE DISEASES INHERITED?

Our DNA is like having 2 almost identical copies of a 23-chapter book. We get one copy from our mother and one from our father, and each chapter (chromosome) contains hundreds to thousands of sentences (genes). However the 23rd chapter is different for males, as they have one copy of the Y chromosome and one copy of the X chromosome (females have 2 almost identical copies of the X chromosome).

The advantage of having 2 almost identical copies (alleles) of each chromosome, and thereby each gene, is that our body may function properly with only one copy of the gene, for some genes. This is why we all carry mutated alleles of genes associated with recessive disorders without manifesting or developing a disease.

However if both parents carry a mutated copy of the same gene their children will have a 25% chance of inheriting both mutated copies and, thereby, develop disease. This is true for genes located in the 22 non-sexual chromosome pairs (autosomes).

figure showing mode of transmission in autosomal and x-linked recessive diseases

In X-linked recessive conditions, boys born to female carriers will have a 50% chance of developing disease. Girls who inherit the mutated allele from their mothers are usually asymptomatic carriers; however due to process known as X-inactivation in females, only the mutated copy of the gene might be expressed and thus result in the development of symptoms.